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Social Psychiatry and Psychiatric Epidemiology

Springer Science and Business Media LLC

Preprints posted in the last 90 days, ranked by how well they match Social Psychiatry and Psychiatric Epidemiology's content profile, based on 12 papers previously published here. The average preprint has a 0.01% match score for this journal, so anything above that is already an above-average fit.

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Sexual orientation inequalities in mental health across adolescence and early adulthood: exploring the contribution of cumulative experiences of bullying and victimisation over time

Khanolkar, A. R.; Becares, L.

2026-08-03 epidemiology 10.64898/2026.07.31.26359405 medRxiv
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Background: Sexual minority ([SM] or LGB+) adolescents experience mental health (MH) inequities and disproportionately high rates of bullying and victimisation. Less is known about the cumulative effects of bullying and victimisation across adolescence on MH in early adulthood, or the moderating role of loneliness and social support in this relationship. Objective: To investigate cumulative effects of bullying and victimisation in adolescence on MH in early adulthood, including the role of loneliness/social support. Methods: Drawing on a UK-wide nationally representative sample of individuals (N=12,872/LGB+ 22%) with self-reported bullying and victimisation assessed at ages 11/14/17/23, and MH (psychological distress/self-harm/attempted suicide) at age 23. Logistic models assessed separate associations between cumulative bullying or victimisation (0, 1, [≥]2times) and MH, and differences by sexual identity (using appropriate interactions), with adjustment for loneliness and social support. Findings: Across adolescence, SM individuals experienced higher prevalence of cumulative victimisation (3 times; gay/lesbian:22%, bisexual:22% vs heterosexual:9%) and bullying (2 times; gay/lesbian:35% and bisexual:27% vs heterosexual:18%). Models revealed substantial inequalities with higher proportions of SM individuals reporting self-harm compared to heterosexual peers with the same levels of experienced victimisation. Among those reporting victimisation 1 and [≥]2 times, 15% (95% CI 13-16%) and 23% (21-25%) of heterosexual individuals reported self-harm, increasing to 41% (33-50%) and 53% (47-59%) for bisexual, and 24% (10-39%) and 49% (40-59%) for gay/lesbian individuals, and 24% (11-38%) and 53% (39-67%) for other SM identities, respectively. Similarly, for heterosexual individuals experiencing victimisation 1 and [≥]2 times, 6% (5-8%) and 13% (11-14%) reported attempted suicide respectively. This increased to 21% (13-29%) and 38% (33-44%) for bisexual, and 17% (6-29%) and 34% (24-44%) for gay/lesbian individuals experiencing victimisation 1 and [≥]2 times, respectively. A key finding was that adjustment for loneliness and lack of peer/family support reduced the proportions reporting adverse mental health by 15-45% among SM but not heterosexual individuals. Similar patterns by sexual identity were found for bullying and all indicators of MH. Conclusions: SM individuals experience higher levels of cumulative bullying and victimisation across adolescence, which is associated with substantially higher rates of mental ill-health in early adulthood. Experiences of loneliness explain MH inequalities to greater extent in SM youth compared to heterosexual peers.

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Mechanisms linking Adverse Childhood Experiences to adolescent mental health: a participatory arts-based study of adolescents accounts.

Hugh-Jones, S.; Farahar, C.; Allder, L.; Foster, A.; Williams, E.; Bhui, K.; Shaughnessy, N.

2026-08-02 psychiatry and clinical psychology 10.64898/2026.07.30.26359340 medRxiv
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Research on adverse childhood experiences (ACEs) has largely relied on retrospective and predominantly adult-focused models that conceptualize mental health difficulties as outcomes of past adversities operating through linear causal pathways. Less is known about how adolescents themselves understand the mechanisms linking adversity and mental health. This study explored young peoples lived experiences of these mechanisms using participatory arts-based methods. Sixty-two young people aged 10-24 years from diverse and often underrepresented backgrounds across England participated in trauma-informed creative workshops. Workshops incorporated multiple artistic modalities, including visual arts, animation, drama, dance, music, film, and creative writing, generating experiential and conversational data. Data were analysed using Framework Analysis within a critical realist approach. Young people did not primarily describe their mental health through narratives linking past adverse events to current outcomes. Instead, they emphasized present-day relational, environmental, and institutional conditions as the most salient influences on wellbeing. Two interconnected pathways were identified: system failures and seeking restoration. System failures referred to ongoing experiences of invalidation, bullying, sensory overwhelm, masking of identity, and unresponsive educational or mental health systems that generated feelings of unsafety. Seeking restoration encompassed actively pursued experiences of belonging, community, validation, sensory regulation, nature connection, creative expression, trust, and authenticity that supported wellbeing. Across pathways, felt (un)safety emerged as the central organizing mechanism through which experiences affected mental health. Findings suggest that adolescents explain their mental health less in terms of historical adversity and more through current experiences of safety, recognition, and belonging. Trauma-informed research and practice may therefore benefit from complementing questions about past adversity with greater attention to what is happening in young peoples lives now and the conditions that support recovery and flourishing.

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Research agenda setting in the mental health of neurodivergent students: A qualitative exploration of students perspectives

Satala, L.; Melashenko, D.; Feeny, A.; Hoxha, D.; Koya, S.; Sanchez-Izquierdo Lozano, C.; Long, Z.; Russell, A.; Murray, A.; Power, L.

2026-07-31 psychiatry and clinical psychology 10.64898/2026.07.29.26359210 medRxiv
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Objectives To identify research priorities for improving the mental health of neurodivergent higher education (HE) students by exploring the perspectives of individuals with lived experience. Design Qualitative study using an online survey. Data was analysed using a deductive-inductive, hybrid semantic thematic analysis. Setting UK higher education institutions. Participants 104 current and former neurodivergent HE students with diverse neurodivergent profiles and intersecting identities. Main outcome measures Participant recommendations regarding priorities for future research on neurodivergent student mental health. Results Six themes were identified and were grouped into (1) general recommendations for research and (2) recommendations specific to neurodivergence within a HE context. Participants prioritised a shift away from medical model approaches towards research informed by social and strengths-based perspectives. Key priorities included improving understanding of diagnostic barriers and misdiagnosis, reducing stigma, investigating institutional barriers within HE, evaluating the effectiveness of support and accommodations and examining the experiences of underrepresented and intersectional groups. Participants emphasised the need for research on more flexible teaching practices, sensory-friendly learning environments, integrated mental health and educational support and alternatives to diagnosis-dependent access to services. Conclusions Future research should move beyond descriptive accounts towards evaluating interventions and current support provision to understand if they improve the mental health of neurodivergent students. Adopting intersectional approaches, moving beyond binary deficit- or strengths-based frameworks and focusing on inclusive, needs-based support rather than diagnosis-led systems are likely to produce more equitable and effective outcomes for neurodivergent students in higher education.

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Longitudinal associations among post-displacement stressors, physical activity, and mental health in Farsi- and Dari-speaking refugees and asylum-seekers in Australia

Kurt, G.; Rostami, R.; McKeon, G.; Rosenbaum, S.; Solaimani, J.; Berle, D.; Silove, D.; Hadzi-Pavlovic, D.; Steel, Z.; Wells, R.

2026-08-12 psychiatry and clinical psychology 10.64898/2026.08.11.26360157 medRxiv
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Background: Post-displacement stressors affect mental health among refugees and asylum-seekers, yet the behavioral mechanisms underpinning this relationship remain understudied. Objective: To examine the role of physical activity in the relationship between post-displacement stressors and mental health outcomes among Farsi/Dari speaking refugees and asylum-seekers in Australia. Methods: Data were drawn from a longitudinal community-based cohort study of 343 Farsi and Dari speaking refugees and asylum-seekers (80 female, 23.3%) in Australia conducted between 2017 and 2019. Data from post-displacement stressors measured at the baseline, physical activity at one-year follow-up, and mental health outcomes (symptoms of posttraumatic stress disorder (PTSD) and depression and personal mastery) at two-year follow-up were included in the study. Longitudinal path analyses were conducted to test the mediating role of moderate-to-vigorous physical activity and sedentary behaviour in the associations between post-displacement stressors and mental health outcomes. Results: After controlling for baseline levels of depression and PTSD, traumatic events, and key demographic characteristics, post-displacement stressors significantly predicted less moderate-to-vigorous physical activity (MVPA) ({beta} = -0.18, 95% CI [-0.292, -0.056]) and more sedentary behavior ({beta} = 0.13, 95% CI [0.011, 0.243]) at one-year follow-up. Less MVPA, in turn, significantly predicted greater symptoms of depression ({beta} = -0.21, 95% CI [-0.353, -0.060]) and lower level of personal mastery ({beta} = 0.19, 95% CI [0.033, 0.327]) while greater time spent in sedentary behavior predicted greater symptoms of depression ({beta} = 0.21, 95% CI [0.060, 0.359]), PTSD ({beta} = 0.24, 95% CI [0.096, 0.386], and lower personal mastery (({beta} = -0.18, 95% CI [-0.336, -0.011]). Significant indirect associations were observed between post-displacement stressors and depressive symptoms and personal mastery through MVPA, and between post-displacement stressors and depressive and PTSD symptoms through sedentary behaviour. Conclusion: These findings provide the first longitudinal evidence that moderate-to-vigorous physical activity and sedentary behavior partially explain the relationship between post-displacement stressors and subsequent mental health outcomes among refugees and asylum-seekers. Addressing these modifiable behaviors may represent targets for future intervention research to promote mental health during resettlement. Keywords: refugees; physical activity; post-displacement stressors; mental health

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Development of a new trauma dataset over 38 years from the Young Finns Study

Saarinen, A.; Asikainen, T.; Lehtimäki, T.; Raitakari, O.; Keltikangas-Järvinen, L.

2026-08-31 psychiatry and clinical psychology 10.64898/2026.08.26.26361417 medRxiv
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Background: Previous trauma research includes many limitations, such as the scarcity of pretraumatic health measurements and assessment of traumatic experiences with a broad scope across the lifespan. To respond to these gaps, we aimed to develop a new, prospective, population-based trauma dataset from childhood to middle age. Methods: We used the Young Finns Study that is a population-based, multi-generational, prospective study (n = 3596 for the main generation). It has started in 1980 (baseline assessment) and includes follow-ups in 1983, 1986, 1989, 1992, 1997, 2001, 2007, 2011/2012, and 2018-2020. From the 38-year follow-up and ten measurement points of the YFS, we collected all relevant trauma variables, including both free-format and structured questions that both the participants and their parents responded to. By a data-driven case-to-case analysis, we developed a scale to numerically capture variation in the quality of the experiences. Results: Our final dataset captured a total of 7769 traumatic experiences. We also developed the Traumatic Experience Severity Scale (TESS), including six subscales such as shamefulness, rarity, danger to life or health, effects on everyday life, human-made physical threat, and whether the target person was within or outside one's household. We also preprocessed the dataset to be later easily interleaved with other psychological, cardiovascular, and epigenetic variables of the YFS. Conclusions: We believe this new trauma dataset with thousands of experiences across the lifespan provides new opportunities to multidisciplinary, lifelong trauma research.

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Greater Mental Health Benefits Following Contemplative-Based Social Resilience Training Among Young Adults with Early-Life Adversity

Eisen, A. M.; Goldin, P.; Mishra, J.; Fromer, E.; Kho, L.; Prather, A. A.; Epel, E. S.; UC Climate Resilience Consortium,

2026-07-23 psychiatry and clinical psychology 10.64898/2026.07.21.26358618 medRxiv
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Emerging evidence suggests that adults with a history of early life adversity (ELA), while more susceptible to psychopathology, may also be particularly sensitive to the benefits of contemplative practices. In the present study, we examined whether ELA was associated with greater mental health benefits following a contemplative-based social resilience training program, administered as a university elective course across all ten campuses of the University of California (n = 321; median age = 21 years; 74% female). While significant improvements in mental health were observed for all participants, those with higher ELA exhibited greater reductions in mental distress (3.5-fold larger, p = .007) and greater increases in well-being (2.5-fold larger, p = .010) relative to those with lower ELA. Replication in future studies and further research on the mechanisms underlying this enhanced benefit may improve our understanding of how adults with a history of ELA recover and may ultimately thrive.

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The Protective Role of Belonging and Socioeconomic Status in Dropout Intent Among Minority Ethnic Students: A Mixed Methods Study

Vaportzis, E.; Khan, M.; George, K. K.

2026-06-22 psychiatry and clinical psychology 10.64898/2026.06.12.26355506 medRxiv
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Improving minority ethnic student retention is a global higher education priority. This mixed-methods study investigated how institutional belonging and socioeconomic status interact to shape dropout intentions among minority university students in the UK (N = 182). Quantitative results revealed that perceived course difficulty and lower subjective socioeconomic status were the strongest predictors of dropout intent. While the interaction between socioeconomic status and difficulty was non-significant, qualitative accounts showed distinct structural vulnerabilities. Financial strain restricted social integration, turning socioeconomic disparities into campus isolation. Conversely, representative curricula, diverse peer networks, and stable cultural in-groups (e.g., religious affiliations, living in the parental home) functioned as essential psychological buffers against academic exhaustion and alienation. Universities must shift from transactional models to sustained structural equity to protect vulnerable student groups.

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Associations of Trajectories of Loneliness and Neighborhood Stability with Depression, Alcohol and Substance Use, and Quality of Life among Women Living with HIV

Barr, P. B.; Edmonds, A.; Aouizerat, B.; Cohen, M.; Cook, J. A.; Friedman, M. R.; Haberlen, S.; Holman, S.; Kempf, M.-C.; Konkle-Parker, D.; Kwait, J. L.; Hanna, D. B.; Pandey, G.; Plankey, M.; Rubin, L. H.; Rubtsova, A. A.; Schwartz, R. M.; Thompson, A. B.; Jones, D. L.; Meyers, J. L.; Wilson, T.

2026-07-16 epidemiology 10.64898/2026.07.14.26358061 medRxiv
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Social relationships are an important social determinant of health. Loneliness, the perceived gap between one's actual and desired relationships, has emerged as an important mechanism through which social relationships impact health. Like other intrapersonal-level factors associated with health, loneliness is influenced by broader social and structural factors, including characteristics of one's neighborhood social environment. Although neighborhood-level protective and risk factors for loneliness and for mental health have been identified, prior studies have often focused solely on self-reported perceptions of the neighborhood environment. Further, few have considered aspects of the neighborhood social environments, such as neighborhood stability (i.e., stability of the community with long or short-term residents), independent of neighborhood socioeconomic conditions. In the current analysis, we explored longitudinal patterns of loneliness in conjunction with neighborhood stability among women with HIV (WWH) enrolled into the MACS/WIHS Combined Cohort Study (MWCCS) from 2014-2019 (N2019=1,394) to examine whether trajectories of loneliness and neighborhood stability were associated with depressive symptoms, non-prescription substance use, past-year cannabis use, number of alcoholic drinks per week, and several domains of quality of life. Loneliness at baseline (Betas = 0.24 - 0.54) and changes in loneliness over time (Betas = 0.11 - 0.26) were associated with each outcome, except for the association between changes in loneliness over time and drinks per week (Beta=0.13, p = 4.14x10-2), which did not persist after correcting for multiple comparisons. Neighborhood stability at baseline was associated with past year cannabis use (Beta=0.26, p = 1.00x10-2), depressive symptoms (Beta=-0.12, p = 1.54x10-3), and overall self-reported health (Beta=-0.08, p = 2.05x10-2). Changes in neighborhood stability across time were not associated with any outcome. Neighborhood stability moderated the association between changes in loneliness and general health perceptions. Our results demonstrate both overall loneliness and changes in loneliness over time have implications for current mental health in WWH, while changes in neighborhood stability did not.

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One-to-one peer support work in mental health services: systematic review and component network meta-analysis

Kotera, Y.; Newby, C.; Charles, A.; Ingall, B.-R.; Uneno, Y.; Ng, F.; Sutton, A. J.; Gray, L. J.; Smith, E. A.; Watson, E.; Davidson, L.; Simpson, A.; Gillard, S.; Puschner, B.; Kidd, S. A.; Mahlke, C.; Nixdorf, R.; Brophy, L.; Brasier, C.; Ashmore, A.; Pomberth, S.; Furukawa, T. A.; Slade, M.

2026-08-10 psychiatry and clinical psychology 10.64898/2026.08.06.26359669 medRxiv
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One-to-one peer support is widely used in mental health services, but the components associated with better outcomes remain unclear. We systematically reviewed randomised controlled trials and conducted additive component network meta-analyses to identify which components of one-to-one peer support worker interventions were associated with outcomes for adults using mental health services. CINAHL Ultimate, Embase, MEDLINE, PsycINFO, CENTRAL, ClinicalTrials.gov and ISRCTN were searched, supplemented by citation tracking, previous reviews and expert consultation. Interventions were coded for seven components: Training and development, Maintaining peer support worker wellbeing, Relationship-building, Social support, Emotional support, Practical support and Cultural adaptation. The review followed PRISMA-NMA reporting guidance and was registered with PROSPERO (CRD42022355291). Thirty-six trials randomised 6,645 participants across nine countries. Only quality of life and recovery yielded estimable component effects at one or more follow-up points. For quality of life, Practical support had a positive incremental estimate at 3 months (standardised mean difference 0.52, 95% confidence interval 0.17 to 0.87); no component showed clear evidence of benefit at 6 months; and at 12 months Social support had a positive estimate (1.57, 0.12 to 3.01), whereas Maintaining peer support worker wellbeing had a negative estimate (-1.66, -3.05 to -0.28). These estimates were not consistent across follow-up points. For recovery, Relationship-building had positive estimates at 6 months (0.90, 0.03 to 1.78) and 12 months (0.50, 0.29 to 0.72). Networks were sparse and often disconnected, and additivity could not be tested in disconnected networks. Current trials do not permit definitive prioritisation of peer-support components. Relationship-building was the most consistent candidate component, but all findings remain provisional. Future trials should prospectively specify, manipulate and measure component delivery.

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Social Determinants of Health and Long COVID in U.S. Children: A Cross-Sectional Study, 2022-2023

Slaughter, D.; Rose-McCully, K.; King, H.; Pratt, C.; Rollins, A. F.; Saydah, S.; Ford, N. D.

2026-07-31 epidemiology 10.64898/2026.07.29.26359222 medRxiv
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Objective We characterized social determinants of health (SDOH) in U.S. children who ever and never had Long COVID. Methods We used cross-sectional data from the 2022-2023 National Health Interview Survey (N=14,993 children 0-17 years). Parents reported child- and household-level information. Long COVID was defined as ever experiencing symptoms lasting [&ge;]3 months that were not present prior to having COVID-19. We produced weighted prevalence estimates by Long COVID status for 3 SDOH domains (Social and Community Context, Healthcare Access and Quality, and Economic Stability) and used Rao-Scott chi-squared tests to examine differences. Results In Social and Community Context, children who ever had Long COVID more often resided in single parent households (33.2% vs. 20.3%; p<0.0001), with someone with severe depression or mental illness (18.5% vs. 8.3%; p<0.0001) or substance abuse (16.7% vs. 8.1%; p<0.0001) or had a lifetime of being disparaged by adults in the home (9.2% vs. 3.9%; p=0.0009). In Healthcare Access and Quality, children who ever had Long COVID more often had public insurance (e.g., Medicaid) (51.3% vs. 41.6%; p=0.02), higher healthcare use, and difficulty paying medical bills (23.2% vs. 12.2%; p<0.0001). In Economic Stability, children who ever had Long COVID had lower parental education, lower food security, and higher participation in social safety net programs (p<0.01 for all comparisons). Conclusion Children who ever had Long COVID more frequently experienced adverse SDOH compared to their peers who never had Long COVID. These findings may help identify children who may benefit from additional resources related to their Long COVID care.

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Childhood Bullying as a Cumulative Health Risk: A Dose-Response Analysis of Peer Victimization and Adult Mental and Behavioral Health Outcomes in Saudi Arabia

Bin Hamdan, D. A.

2026-08-19 epidemiology 10.64898/2026.08.17.26360648 medRxiv
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Childhood peer victimization is increasingly recognized as an adverse childhood experience (ACE) with long-term consequences for population health. Most existing research treats bullying as a binary exposure, obscuring the dose-response mechanisms through which cumulative victimization generates escalating health risks. This methodological gap is particularly consequential for prevention, and evidence from the Gulf Cooperation Council (GCC) region remains systematically sparse. This study conducts a national dose-response analysis of childhood bullying and adult health outcomes in Saudi Arabia using the WHO Adverse Childhood Experiences International Questionnaire (ACE-IQ), administered to a nationally representative sample of 10,156 adults by the King Abdullah International Medical Research Center (KAIMRC) and the National Family Safety Program (NFSP), Ministry of National Guard Health Affairs (2013). We conducted a cross-sectional secondary analysis examining associations between bullying frequency and five adult health outcomes: physician-diagnosed anxiety disorder, suicidal ideation, sleep disturbance, tobacco smoking, and substance use. The analytical sample comprised 4,632 adults reporting any childhood peer victimization. Binary logistic regression models adjusted for socioeconomic status, gender, age cohort, parental supervision, and family structure were estimated separately for each outcome. Three pre-specified hypotheses were tested: (H1) any bullying exposure is associated with higher odds of adverse adult health outcomes; (H2) increasing frequency follows a dose-response gradient; and (H3) associations are amplified among socioeconomically disadvantaged respondents and attenuated among those reporting higher parental attention. A consistent dose-response gradient was observed. Frequent victims showed substantially higher adjusted odds of tobacco smoking (OR = 6.55, 95% CI 5.81-7.32) and substance use (OR = 2.71, 95% CI 2.26-3.31) compared to those never bullied. Internalizing outcomes showed significant gradients for anxiety disorder (OR = 0.37, 95% CI 0.16-0.86) and sleep disturbance (OR = 0.39, 95% CI 0.20-0.76). Religion-targeted verbal victimization was the strongest independent predictor of suicidal ideation (OR = 3.01, 95% CI 1.83-4.97) and substance use (OR = 3.24, 95% CI 1.92-5.46), independent of bullying frequency. Bullying-health associations were significantly amplified among socioeconomically disadvantaged respondents, consistent with fundamental cause theory. Parental supervision was protective against substance use (OR = 0.45, 95% CI 0.30-0.67) but showed a paradoxical positive association with suicidal ideation, interpreted as a reactive parenting effect in the cross-sectional design. These findings establish childhood bullying as a cumulative, graded public health risk whose consequences are amplified by structural disadvantage. Prevention strategies must extend beyond school-level programs to address structural inequalities and integrate family-based and community-level protective factors. This study contributes population-level ACE evidence from the underrepresented GCC region and provides a foundation for integrating bullying prevention into Saudi Arabia's Vision 2030 national health agenda.

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Awareness and perceptions of social prescribing among university students in the UK

Bone, J. K.; Fancourt, D. K.; Hayes, D.

2026-07-09 epidemiology 10.64898/2026.07.07.26357397 medRxiv
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Universities provide a key opportunity to deliver social prescribing, a care pathway that aims to connect people with non-medical forms of support within the community to address their social, emotional, and practical needs. However, it is unclear whether students in the UK are aware of social prescribing and whether it would be an acceptable form of support. We surveyed 775 university students across the UK who completed a questionnaire measuring awareness and perceptions of social prescribing. We described awareness and attitudes and used logistic regression to explore how they differed according to individual characteristics. We found an awareness-attitude paradox. Only 25% of students were aware of social prescribing, but attitudes were overwhelmingly positive once explained: 97% thought it could support mental health and wellbeing; 95% believed universities should offer it; and 89% would accept social prescribing if offered by a healthcare professional. Students who were older, postgraduates, and had English as their first language were among those with higher odds of being aware of social prescribing, but positive attitudes were more evenly reported across the sample. Our findings indicate that implementation efforts should prioritise awareness-raising and clear referral pathways, rather than increasing students' willingness to engage with social prescribing.

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Design and evaluation of a youth co-designed trauma-informed public health resource for use in public sector settings in England

Hugh-Jones, S.; Allder, L.; Baker, E.; Butcher, I.; Sansoy, H.; Shaughnessy, N.; Bhui, K.

2026-08-10 psychiatry and clinical psychology 10.64898/2026.08.05.26359401 medRxiv
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Background: Trauma-informed approaches (TIAs) are increasingly implemented across public-sector settings to improve support for young people affected by adverse childhood experiences (ACEs). However, practitioners often report difficulties translating broad trauma-informed principles into everyday practice, and young people are rarely involved in developing resources intended to support implementation. Aim: To co-design, implement and undertake a preliminary evaluation of a youth-led trauma-informed resource for professionals working with young people in public-sector settings in England. Methods: The study formed part of the UKRI-funded Attune programme and employed Accelerated Experience-Based Co-Design (AEBCD). Eighteen adolescents with lived experience of ACEs and 16 professionals from nine public-sector settings participated in three regional co-design workshops. Findings from a prior arts-based lived experience study informed the workshops. Participants collaboratively developed Validating Voices, a low-cost resource designed to increase validating interactions between professionals and young people. The resource was subsequently introduced into nine organisations and evaluated using staff surveys and semi-structured interviews. Results: Co-design participants identified professional invalidation of young peoples experiences, identities, needs and emotions as an under-recognised contributor to mental health. The resulting resource combined discussion cards, creative activities, role-play and organisational reflection exercises to promote validating practices. Five organisations implemented the resource and reported it to be feasible. Flexible local adaptation was common, while more participatory role-play elements proved harder to implement consistently. Staff observed increased opportunities for disclosure, reflection, peer connection and professional curiosity about young peoples experiences. Staff reported listening differently to young people and, in some settings, implementing changes in response to young people's recommendations. Conclusions: Youth-led co-design identified validation as a practical and meaningful mechanism for operationalising trauma-informed principles in everyday professional practice. With refinements, Validating Voices shows promise as a resource to support more relational, collaborative and trauma-informed responses to young people in public sector settings.

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Rumination as a cognitive vulnerability factor in perinatal bereavement: evidence from the CARING study

Ravaldi, C.; Mosconi, L.; Raduzzi, G.; Olmi, C.; Neri, I.; Cocchi, E.; Vannacci, A.

2026-06-19 psychiatry and clinical psychology 10.64898/2026.06.16.26355798 medRxiv
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Purpose. Perinatal loss is associated with a high risk of persistent psychological distress, including prolonged grief, depression, anxiety, and post-traumatic stress symptoms. Cognitive processes such as rumination may play a crucial role in maintaining and amplifying distress following loss, yet their specific contribution in perinatal bereavement remains underexplored. Methods. The CARING (Cognitive Analysis and Rumination INvestigation in perinatal Grief) study employed a cross-sectional design involving 298 parents who experienced perinatal loss within the previous five years. Participants completed an anonymous online survey including measures of depressive rumination (Ruminative Response Scale, RRS), angry rumination (Anger Rumination Scale, ARS), perinatal grief (Perinatal Grief Scale, PGS), general psychopathology (SCL-90), and post-traumatic stress symptoms (NSESSS). Non-parametric analyses were conducted to examine associations between rumination patterns and psychological outcomes. Results. Higher levels of rumination were significantly associated with greater perinatal grief, depressive and anxiety symptoms, and post-traumatic stress. Depressive rumination showed consistently stronger associations with all outcomes compared to angry rumination. Participants presenting both depressive and angry rumination exhibited the highest levels of grief intensity, psychological distress, and PTSD symptoms, suggesting a graded relationship between rumination patterns and severity of distress. Rumination levels were not significantly associated with gestational age at loss or with having received psychological support. Conclusions. Rumination, particularly in its depressive form, appears to function as a transdiagnostic cognitive vulnerability factor in perinatal bereavement. These findings highlight rumination as a potential target for early screening and tailored psychological interventions aimed at reducing long-term distress following perinatal loss.

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Assessing adverse childhood experiences and mental health status in diverse and underrepresented young people: advancing Inclusive research

Bhui, K.; Kirk, M.; Butcher, I.; Fazel, M.; Ma, M.; Cooke, P.; Farahar, C.; Foster, A.; Harris, K.; Sansoy, H.; Havers, L.; Shaughnessy, N.; Hugh-Jones, S.; Allder, L.; Mankee-Williams, A.

2026-07-22 psychiatry and clinical psychology 10.64898/2026.07.21.26358568 medRxiv
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Background: Young people impacted by adverse childhood experiences (ACEs) are often underrepresented in mental health research. Aims: This paper aims to advance inclusive research on ACEs by 1) describing co-designed recruitment and engagement methods in a national project on ACEs (Attune), 2) characterising a highly marginalised cohort of young people using identity descriptors co-designed with participants, and 3) reporting associations between ACEs, identity characteristics and mental health outcomes. Methods: A trauma-aware approach to engage under-represented young people was co-developed with a national youth advisory group, lived experience researchers, and trusted community partners. Our co-created purposive sampling strategy recruited 74 young people, aged 10 to 24 years, across England, seeking representation by age, sex, gender identity, sexual orientation, ethnicity, neurodivergence, and geographic location. Participants completed validated self-report measures of ACEs, life events, and mental health. Descriptive, correlational and regression analyses examined cohort characteristics and associations between ACEs, identity characteristics, and mental health measures. Results: The final cohort included participants identifying as non-White British (39.5%), non-binary/other gender (25%), and neurodivergent (30%). Half of participants reported exposure to at least one ACE. Analyses identified patterns consistent with prior literature. In addition, ACEs and barriers related to being neurodivergent were associated with increased depression and anxiety symptom severity. Non-binary gender identity was associated with anxiety. We did not observe associations of ACEs or mental health measures, with sex or ethnicity. Conclusions: Under-represented groups can be reached via co-created engagement methods informed by lived experience. We identified important associations between ACEs, identities, and mental health outcomes.

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The Inflammatory Cascade Through Discrimination, Socioeconomic Status, and Body-Mass Index

Espero, M.

2026-07-01 epidemiology 10.64898/2026.06.24.26356254 medRxiv
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C-Reactive Protein (hs-CRP) is a common marker for human inflammation, a response to perceived threat and precipitate to many compromising health conditions. Previous work demonstrated that in addition to other biological features that may be predictive and explanatory of variance in inflammation, psychosocial influences may play a role. The present work uses structural equation modeling to examine pathways including socioeconomic status (SES), psychological capital (PsyCap), and perceived discrimination (Discrim) -insofar as they explain variance in hs-CRP, potentially moderated by neurological lateralization (handedness). Body mass index (BMI), an indicator of body composition, stood as the strongest predictor of the obesity-related inflammatory marker (ORIM). On average, females are predicted to have higher hs- CRP scores than males. The psychosocial constructs were estimated to have little to no effect on inflammation (via hs-CRP) in the analysis sample (ADD Health Study) in either group (left and right-handers) although a small, statistically non-zero indirect path is found in the retained model for right-handed participants (given statistical power for estimation). With this finding, contextual effect estimates are provided with regard to the effect of perceived discrimination on hs-CRP given the range of SES and BMI.

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Developmental trajectories of suicidality and lifestyle factors across adolescent severity profiles

Crethar, M.; Hermens, D. F.; Prince, T.; Mills, L.; Brander-Peetz, N.; Boyes, A.

2026-08-22 psychiatry and clinical psychology 10.64898/2026.08.19.26360854 medRxiv
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Background: Adolescent suicide is a leading cause of death in Australia, arising from multiple determinants. Psychological distress, lifestyle behaviours and socioeconomic factors are associated with adolescent suicidality. Existing research has predominantly employed cross-sectional designs, limiting our understanding of how these factors interact over time. Longitudinal and data-driven approaches are needed to help identify the factors associated with the emergence of suicidality throughout adolescence. Method: Participants aged 12-17 years completed longitudinal measures of suicidal ideation, psychological distress, sleep quality, mindfulness, physical activity, eating habits, and social connectedness. Subgroups were determined via hierarchical cluster analysis, based on average scores across later timepoints (9-15). ANOVA and pairwise effect size calculations were used to compare clusters across variables, and their preceding developmental trajectories were examined using generalised additive mixed models (across earlier timepoints; 1-8). Clusters were also compared on self-reported wellbeing, long-term suicidality, and socioeconomic status. Result: Three clusters characterised by low-, moderate-, and high-severity of suicidal ideation and psychological distress, and poorer sleep, social connectedness, physical activity, mindfulness, and eating habits were identified. Across earlier timepoints, the high-severity group showed consistently elevated suicidality and deteriorating wellbeing and lifestyle scores. Conclusion: Youth with high levels of suicidality had greater psychological distress, lower wellbeing, lower socioeconomic status, and poorer lifestyle behaviours. This subgroup was also found to have poorer scores on wellbeing and lifestyle factors in their early adolescence. Findings highlight the importance of early, preventative interventions targeting both mental health and lifestyle factors to reduce suicidality in adolescents.

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Identifying adverse experiences in childhood in the Born in Bradford Birth Cohort children

Lam, N.; Wadman, R.; Watmuff, A.; Gilbody, S.

2026-08-21 epidemiology 10.64898/2026.08.18.26360723 medRxiv
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Adverse experiences in childhood (AEs) typically refer to undesirable events, including child maltreatment and household challenges. Various survey measures and linked routine data in the Born in Bradford Birth Cohort (BiB) datasets can provide a contemporary understanding of the distribution of AEs in the population and the factors related to their occurrence. This study aimed to identify relevant survey data on AEs collected from BiB families and to summarise the prevalence of AEs from birth to early adolescence (ages 12-15) among BiB children. We included BiB children who participated in the follow-ups - Growing Up (GUp, n=5253) and Age of Wonder (AoW, n=2662). Four AEs were identified - parental mental illness, parental substance use, children not living with both parents in the same home, and being bullied by peers. The survey data included 1) health, substance use, living arrangements, and children's bullying experience reported by parent(s) at baseline (2007-2011, around birth) and/or GUp (2017-2022, during mid-childhood), and 2) bullying experience and living arrangements self-reported by children at AoW (2022-2024, during early adolescence). Additionally, we included parents' primary care records regarding any mental illness or substance use. Overall, 3371 (64.2%) children experienced at least one of the four AEs between birth and early adolescence. The most common AE was parental mental illness, whereas parental substance use was the least common. Children across all sociodemographic groups experienced AEs. Asian children, or those whose mothers were not materially deprived, appeared less likely to experience AEs. Conversely, children of White or Mixed ethnicities, or whose mothers were materially deprived, were more likely to experience AEs. Consistent with similar studies, our findings show that AEs are widespread but disproportionately affect certain sociodemographic subgroups among BiB children. These disparities can be reduced by early-years policies that provide practical family support, guided by continuously collected AE data.

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Mental health contact gaps among adults in Peru: a cross-sectional analysis of a nationally representative survey

Ruiz-Grosso, P.; Macedo-Orrego, L.; Rodriguez-Vargas, D.; Rivera-Encinas, M.; Arosemena, A.; Carazas-Vera, M.; Sagastegui, A.; Zevallos-Bustamante, S.

2026-08-22 psychiatry and clinical psychology 10.64898/2026.08.19.26360808 medRxiv
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Objective. To estimate lifetime and 12 month mental health contact gaps among Peruvian adults with survey-defined mental disorders, and to describe inequalities in contact, perceived need for care, and mental health service use. Methods. We analyzed the information for adults of the 2022 Peruvian National Mental Health Survey, a cross-sectional household survey. The primary outcome was the survey-weighted proportion of adults with a 12 month mental disorder who reported no contact with an included source of mental health-related care during that period; the lifetime contact gap was descriptive. Perceived need was assessed using two derived 12 month perceived-need measures based on direct ENSM variables and service contact routing items. Analyses incorporated weights, strata, and clusters. Adjusted prevalence ratios were estimated using survey weighted Poisson models. Results. The dataset contained information on 13,840 individuals; 13,833 had complete survey-design information. Contact gap denominators were 3,927 for lifetime disorders and 1,649 for 12-month disorders. The lifetime and 12-month contact gaps were 61.0% (95% CI 58.4-63.7) and 84.5% (95% CI 81.5-87.6), respectively. Rural estimates exceeded urban estimates in both periods; after adjustment, poverty and rural residence were associated with the lifetime gap, and extreme poverty with the 12-month gap. Among individuals meeting survey-based criteria for one or more 12-month mental disorders, 37.3% (95% CI 33.4-41.4) reported self-perceived need, whereas 25.6% (95% CI 21.8-29.8) reported that need had been identified by others. Annual psychological and psychiatric service use was 3.7% and 1.1%, respectively. Conclusions. Mental health contact gaps were high, particularly for one or more 12-month mental disorders, and were associated with social and territorial variables. These contact measures do not establish adequate, continuous, or effective treatment, which needs to be addressed to understand the impact of the Peruvian mental health reform.

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The lasting impact of NICU admission on the parents of children with non-cardiac congenital anomalies: trauma, mental health, and unmet support needs 5-16 years following discharge

Wilkie, L. J.; Malarbi, S.; Ryan, N. P.; Wood, A. G.

2026-06-26 psychiatry and clinical psychology 10.64898/2026.06.24.26354566 medRxiv
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Background Despite growing evidence that interventions targeting parental distress are associated with improved outcomes in families of children with life-threatening conditions, mental health research is limited for parents of NICU graduates treated for non-cardiac congenital anomalies. Aims To examine the prevalence and severity of mental health difficulties and post-traumatic stress, including subthreshold trauma-related distress, in these parents. Method Participants were 103 parents (n=86 female) of children, aged 5-16 years, who were treated in the NICU for non-cardiac congenital anomalies (e.g., congenital diaphragmatic hernia [CDH], tracheo-oesophageal fistula and/or oesophageal atresia [TOF-OA], abdominal wall defects) at a large tertiary-level paediatric hospital in Australia. Validated measures of mental health (DASS-21) and post-traumatic stress (PCL-5) were administered using an online cross-sectional survey. Whole group and diagnostic subgroup scores were compared with normative data. Comparisons between parents of primary school and high school-aged children enabled the examination of differences in unmet support needs according to their child's developmental stage. Results Seventy-four percent of parents reported experiencing mental health difficulties since their child's congenital anomaly diagnosis, yet only 44.7% had accessed professional mental health support. The mean DASS-21 'Stress' score was significantly elevated relative to Australian population norms (p<0.0005). Scores on the PCL-5 indicated that 9.4% met DSM-5 criteria for provisional PTSD diagnoses and a further 20.8% met subthreshold PTSD criteria. Importantly, 50% of parents reporting subthreshold PTSD had not accessed professional psychological support. Mental health concerns appeared more prominent among parents of children with TOF-OA and CDH, as well as parents of high school-aged children. Conclusions Parents report elevated stress and clinically meaningful subthreshold PTSD symptoms long after their child's NICU discharge, yet many do not access formal support. These findings highlight the importance of trauma-informed approaches to ongoing mental health surveillance and support for parents of NICU graduates with non-cardiac congenital anomalies.